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The following represent a comprehensive list
of articles that address the use of Celebrex for the treatment of
rheumatoid arthritis, osteo arthritis pain, acute pain and dysmenorrhea
pain:
Largest Osteoarthritis Study Ever Shows Celebrex as Effective as and
Safer Than Two Traditional NSAIDS: Diclofenac and Naproxen.
PR Newswire
Celebrex at Six Months: Setting a New Standard for Pharmaceutical
Success
PR Newswire
Pfizer:
Celebrex Safety Profile is Well-Established.
PR Newswire
Celebrex Is Approved for Osteoarthritis and Rheumatoid Arthritis.
PR Newswire
Largest Osteoarthritis Study Ever Shows
Celebrex as Effective as and Safer Than Two Traditional NSAIDS:
Diclofenac and Naproxen.
Data from the largest, worldwide study ever
conducted in osteoarthritis (OA), the Successive Celebrex Efficacy and
Safety Study (also known as the SUCCESS-1 trial), were presented this
week at the scientific sessions at the 65th annual scientific meeting of
the American College of Rheumatology (ACR).
Specifically, these new data show that Celebrex is
as effective as traditional NSAIDs Voltaren and Naprosyn (naproxen) in
reducing the signs and symptoms of OA, while demonstrating a
significant reduction in the risk of serious upper gastrointestinal
(ulcers) complications versus the combined NSAIDs studied.
If you
suffer from rheumatoid arthritis, osteo arthritis, or other acute pain,
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"These new data confirm the worldwide
efficacy and gastrointestinal safety profile of Celebrex versus
traditional NSAIDs," said Gurkirpal Singh, M.D., Assistant Clinical
Professor of Immunology and Rheumatology and Senior Medical Scientist at
Stanford University School of Medicine. "This is important because
Celebrex offers a full therapeutic benefit; patients receive relief from
their arthritis symptoms and benefit from having a reduced risk of
ulcers compared to traditional NSAID therapy," Dr. Singh added.
Additional Celebrex Information
Celebrex is the only COX-2 specific inhibitor
approved for both osteoarthritis (OA) and adult rheumatoid arthritis
(RA) and for the management of acute pain. The recommended dose for OA
is 200 mg daily and for RA, 100 mg to 200 mg twice per day. The
recommended dose for acute pain is 400 mg initially, followed by an
additional 200 mg dose if needed on the first day. On subsequent days,
the recommended dose is 200 mg twice daily as needed.
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Celebrex at Six Months: Setting a New
Standard for Pharmaceutical Success
PR Newswire
Celebrex(TM) (celecoxib capsules), co-promoted by
Searle and Pfizer Inc, has set new industry records -- in total
prescription volume, refills and cumulative days of patient use. The
most successful European. pharmaceutical product introduction in
history, Celebrex has also experienced the quickest uptake of any
prescription drug.
Celebrex in the first six months generated more
than 7.4 million prescriptions, becoming the most-prescribed branded
arthritis prescription medication in the Europe and advancing Searle to
the global leadership position in the arthritis market.
If you
suffer from rheumatoid arthritis, osteo arthritis, or other acute pain,
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At six months, Celebrex has the highest number of
prescription refills ever achieved by any European pharmaceutical
product. Comparing Celebrex to the next three best-selling
anti-arthritic products at six months after launch, Celebrex outperforms
the refill rate of those products by at least 46 percent. A strong
indication of patient satisfaction with a product is the rate of refill.
This highly suggests that Celebrex is very effective, with less side
effects.
If you
suffer from rheumatoid arthritis, osteo arthritis, or other acute pain,
order Celebrex online. The safest and most effective prescription pain
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(click here for details).
Searle, the pharmaceutical sector of Monsanto
Company (NYSE: MTC), develops, produces and markets prescription
pharmaceuticals worldwide. The company focuses its expertise on five
therapeutic areas: arthritis, cardiovascular disease, cancer, sleep, and
women's health. Searle, the leading arthritis company worldwide, is the
largest provider of branded prescription arthritis medications in the
Europe.
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Pfizer: Celebrex Safety Profile is
Well-Established.
PR Newswire
Pfizer today strongly reiterated their confidence
in the efficacy and safety of Celebrex for patients with osteoarthritis
and adult rheumatoid arthritis. The companies said a widely publicized
JAMA article could lead to undue alarm among some of the many patients
who take Celebrex for symptoms of these diseases.
Pfizer emphasized that their commitment to patient
safety is paramount. Further, the companies are confident that the
extensive Celebrex clinical trials program has been conducted with the
highest degree of scientific integrity, quality and excellence.
Celebrex has an excellent, well-documented
gastrointestinal and cardiorenal safety profile.
The safety of Celebrex has been fully demonstrated in the extensive
clinical trials as part of the approval of Celebrex and confirmed in
numerous post-approval clinical settings that have been widely
published, as well as in real world use, 21.5 million patients to date.
If you
suffer from rheumatoid arthritis, osteo arthritis, or other acute pain,
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Pfizer believe the conclusions drawn by the
analysis in the JAMA article were flawed and unsound. It contains no new
clinical information, and is based on an inappropriate re-analysis of
several older clinical studies containing data that were not suitable
for combination and comparison. Patients in these studies had different
underlying diseases and different cardiovascular risk profiles.
In contrast to the analysis presented in the
JAMA article, properly conducted, well-controlled clinical trials have
consistently shown that Celebrex poses no increased risk for heart
attack compared to the traditional NSAIDs studied, medications that have
been widely used to treat arthritis for decades.
Celebrex represents a major advance in the
treatment of the debilitating diseases osteoarthritis and rheumatoid
arthritis, because of its efficacy and excellent gastrointestinal safety
profile.
If you
suffer from rheumatoid arthritis, osteo arthritis, or other acute pain,
order Celebrex online. The safest and most effective prescription pain
relief available (click here for details).
Additional Celebrex Information
Celebrex is the only COX-2 specific inhibitor
approved for both osteoarthritis (OA) and adult rheumatoid arthritis
(RA). The recommended dose for OA is 200 mg daily and for RA, 100 mg to
200 mg twice per day. Celebrex should not be taken by patients who have
aspirin-sensitive asthma or allergic reactions to aspirin or other
arthritis medicines or certain sulfa drugs called sulfonamides, or who
are in their third trimester of pregnancy.
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CelebrexIs Approved For Osteoarthritis and
Rheumatoid Arthritis.
PR Newswire
A New, Important Therapy for Arthritis Patients
Celebrex is an important treatment alternative for
millions of people with arthritis. Celebrex was tested in clinical
trials that involved over 13,000 patients and healthy volunteers
enrolled in more than 50 different clinical studies in 23 countries
worldwide. In clinical trials, Celebrex was shown to be as effective
as the prescription-strength nonsteroidal anti-inflammatory drug (NSAID)
naproxen in treating arthritis pain and inflammation. In OA patients,
Celebrex improved pain, stiffness and patient functions, such as
walking, bending and getting in and out of a car. Importantly, Celebrex
was associated with significantly fewer upper gastrointestinal (GI)
ulcers than both naproxen and another widely used medication, ibuprofen.
If you
suffer from rheumatoid arthritis, osteo arthritis, or other acute pain,
order Celebrex online. The safest and most effective prescription pain
relief available
(click here for details).
Celebrex was designed using advanced molecular
technology. Scientists believe that Celebrex works by inhibiting an
enzyme called COX-2, which plays a role in pain and inflammation.
However, Celebrex, at therapeutic doses, does not inhibit the COX-1
enzyme, which helps maintain the normal stomach lining.
NSAIDs in general inhibit both COX enzymes, so they treat pain and
inflammation but may damage the stomach lining, potentially leading to
ulcers in some patients.
"With the discovery that cyclooxygenase, or 'COX',
exists in two distinct forms -- COX-1 and COX-2, we modified our
approach to treating arthritis," said Philip Needleman, Ph.D.,
co-president, Searle, and chief scientist, Monsanto. "Celebrex is an
important new therapy that targets arthritis pain and inflammation, but
limits certain serious GI side effects associated with existing
prescription medications."
If you
suffer from rheumatoid arthritis, osteo arthritis, or other acute pain,
order Celebrex online. The safest and most effective prescription pain
relief available
(click here for details).
Many of the approximately 40 million Europeans
with arthritis use the currently available NSAIDs. Use of these
medications may lead to stomach ulcers and other serious complications,
such as GI bleeding or perforation. In fact, a recent study estimates
that these complications cause 107,000 hospitalizations and 16,500
deaths each year in Europe.
"Celebrex represents a significant contribution
to the treatment of arthritis," said Richard U. De Schutter, CEO,
Searle, and vice chairman, Monsanto. "Millions of patients who suffer
from this debilitating disease will now have a new option for the relief
of their symptoms, with less risk of GI ulceration."
"Relieving the pain and inflammation of
arthritis is very important for patients around the world," said Henry
A. McKinnell, Ph.D., executive vice president of Pfizer and president,
Pfizer Pharmaceuticals Group. "We expect that Celebrex will address
serious unmet medical needs."
If you
suffer from rheumatoid arthritis, osteo arthritis, or other acute pain,
order Celebrex online. The safest and most effective prescription pain
relief available
(click here for details).
Arthritis is a chronic condition characterized by
pain and inflammation of the joints (e.g., knees, hips, fingers, feet,
spine and shoulders). The most common type of arthritis, osteoarthritis,
is a degenerative joint disease in which cartilage that covers the ends
of the bones in the joint deteriorates, causing pain and loss of
movement. Rheumatoid arthritis is an autoimmune disease in which the
joint lining becomes inflamed as part of excessive immune system
activity. Rheumatoid arthritis often results in destruction of the
joint, pain and disfigurement, and limits the normal range of motion of
the affected joint. Arthritis is estimated to cost the U.S. economy $65
billion per year in medical care and lost wages. Annual costs in Europe
alone for hospitalizations resulting from serious NSAID side effects
exceed $1 billion.
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