Celebrex
Arthritis Relief Proven Pain Relief With Celebrex
(free next day postage when you buy Celebrex online now.)
Are you tired of athritis
pain, do you want effective arthritis relief so you can resume your
daily activities? Today, there is a proven arthritis treatment
that gives relief from arthritis pain. Celebrex, provides excellent 24 hour relief from arthritis pain. Celebrex is one of the first nonsteroidal anti-inflammatory drugs (NSAIDs)
to selectively inhibit primarily the Cox-2 enzyme, while sparing the
Cox-1 enzyme that is responsible for protecting the delicate lining of
the stomach. This means relief from arthritic pain without disrupting
the delicate lining of the stomach.
Traditional NSAIDs, such as, Voltaren, Naprosyn,
Lodine, etc. target both of these enzyme, subsequently, these pain
relief medications are associated with a high incidence of
gastro-intestinal side effects including dyspepsia, bleeding, ulceration
and perforation of the stomach and/or small or large intestine.
Celebrex has shown to be more effective as the
traditional NSAIDs with a decreased potential for the above mentioned
side effects.
Celebrex has been shown in numerous clinical
studies to relieve the pain associated with arthritis. In addition,
Celebrex is prescribed by doctors for the following conditions:
 Osteoarthritis
pain (form of arthritis, occurring mainly in older persons, that is
characterized by chronic degeneration of the cartilage of the joints).
 Rheumatoid
arthritis pain (chronic autoimmune disease with inflammation of the
joints and marked deformities).
 Management
of acute pain in adults (short term pain secondary to dental procedure,
surgery, etc.).
 Treatment
of primary dysmenorrhea pain (moderate to severe menstrual pain).
Free yourself
from arthritic pain, buy the safest Celebrex arthritis pain relief
online now
(click
here for details).
Additional Information on
Celebrex Arthritis Relief
The following Celebrex arthritis
relief
information has been compiled from a variety of resources in order to
give you details concerning
the use of Celebrex for Arthritis relief.
 Why is Celebrex recomended by so many doctors
for the treatment of arthritis or arthritis relief?
 Celebrex is a nonsteroidal anti-inflammatory drug (NSAID) that
exhibits anti-inflammatory, analgesic, and antipyretic activities.
Celebrex provides excellent arthritis relief without damaging the
sensitive lining of the stomach. Celebrex with allow you to return to
your daily activities without having arthritic pain.
Free yourself
from arthritic pain, buy Celebrex arthritis pain relief online now
(click here for details).
Why is Celebrex sometimes referred to as celecoxib?
Celecoxib is the generic name for Celebrex. The generic name represents
the medications nonproprietary or chemical name, whereas, the brand
name is the name a pharmaceutical give to a medication for marketing
purposes.
How does Celebrex work?
NSAIDs target an enzyme called cyclooxegenase that is responsible for
much of the inflammation behind pain. However, it turned out there are
two types of this enzyme. Cox-2 was behind the inflammation, while cox-1
actually protects the stomach lining. Unfortunately, most NSAIDs target
both which often can result in ulcers in the stomach.
The mechanism of
action of Celebrex is believed to be due to inhibition of prostaglandin
synthesis, primarily via inhibition of cyclooxygenase-2 (COX-2), and
at therapeutic concentrations in humans, Celebrex does not inhibit the
cyclooxygenase-1 (COX-1) isoenzyme.
Scientists have shown
that a more specific drug that targeted just cox-2, would alleviate
pain and inflammation while not effecting the delicate lining of the
stomach.
Free yourself
from arthritic pain, buy the safest Celebrex arthritis pain relief
online now
(click
here for details).
What
Celebrex clinical studies have been done?
In studies of about 13,000 patients, Celebrex appeared to work much
better than prescription-strength naproxen in-patients with
osteoarthritis. In rheumatoid arthritis sufferers, Celebrex was even
more beneficial in relieving arthritic pain than the popular NSAIDs.
Clinical testing involving some 4,500 endoscopies
- probing a tube into patients' stomachs to see if ulcers were forming
even before they experienced symptoms. Some 25 percent to 40 percent of
patients taking ibuprofen or naproxen showed these mini-ulcers, vs. 1
percent to 2 percent of patients taking Celebrex.
Celebrex has demonstrated significant reduction
in joint pain secondary to osteoarthritis (OA) compared to a placebo
(sugar pill). Celebrex was evaluated for treatment of the signs and
the symptoms of OA of the knee and hip in approximately 4,200 patients
in placebo- and active-controlled clinical trials of up to 12 weeks
duration. In patients with OA, treatment with Celebrex 100 mg twice per
day or 200 mg once per day resulted in improvement in WOMAC (Western
Ontario and McMaster Universities) osteoarthritis index, a composite of
pain, stiffness, and functional measures in OA.
In three 12-week studies of pain accompanying OA
flare, Celebrex doses of 100 mg twice per day and 200 mg twice per day
provided significant reduction of pain within 24-48 hours of initiation
of dosing. At doses of 100 mg twice per day or 200 mg twice per day the
effectiveness of Celebrex was shown to be similar to that of naproxen
500 mg BID. Doses of 200 mg twice per day provided no additional benefit
above that seen with 100 mg twice per day. A total daily dose of 200 mg
has been shown to be equally effective whether administered as 100 mg
twice per day or 200 mg once per day.
Celebrex has demonstrated significant reduction
in joint tenderness/pain and joint swelling in Rheumatoid Arthritis
compared to placebo (sugar pill). Celebrex was evaluated for
treatment of the signs and symptoms of RA in approximately 2,100
patients in placebo- and active-controlled clinical trials of up to 24
weeks in duration. Celebrex was shown to be superior to placebo in these
studies, using the ACR20 Responder Index, a composite of clinical,
laboratory, and functional measures in RA. Celebrex doses of 100 mg
twice per day and 200 mg twice per day were similar in effectiveness and
both were comparable to naproxen 500 mg twice per day.
 Conclusions, some 90 percents of the
individuals involved in these clinical studies reported excellent relief
from pain associated with use of Celebrex. The medication allowed these
individuals resume the activities of daily life free from arthritic
pain.
Free yourself
from arthritic pain, buy Celebrex arthritis pain relief online now
(click here for details).
Can I get Celebrex over the counter?
No, Celebrex is a prescription medication and should only be taken when
prescribed by a licensed physician.
However, secondary to the advent of the
internet individuals can now order lifestyle medication, such as,
Celebrex online. You are simply asked to complete a medical
questionnaire which is subsequently reviewed by a doctor, once approved
your Celebrex order will be shipped promptly to your home or office.
Free yourself
from arthritic pain, buy the safest Celebrex arthritis pain relief
online now
(click
here for details).
Should pregnant or nursing women take Celebrex?
There are no studies in pregnant women or nursing mothers. Therefore,
Celebrex should not used during pregnancy or while nursing. In late
pregnancy Celebrex may cause premature closure of the ductus arteriosus.
It is not known whether this drug is excreted in human milk. Because
many drugs are excreted in human milk and because of the potential for
serious adverse reactions in nursing infants from Celebrex is not
recommended in this population.
What is the appropriate dose of Celebrex?
As with any medication, the lowest dose of Celebrex should be sought for
each patient.
For relief of the signs and symptoms of
osteoarthritis the recommended oral dose is 200 mg per day administered
as a single dose or as 100 mg twice per day (these doses are only
generalizations; doses may vary depending on the patient's medical
history).
For relief of the signs and symptoms of rheumatoid
arthritis the recommended oral dose is 100 to 200 mg twice per day
(these doses are only generalizations; doses may vary depending on the
patient's medical history).
For relief of the signs and symptoms of menstrual
cramps or acute pain the recommended dose for acute and menstrual pain
is 400 mg initially, followed by a 200-mg dose if needed on the first
day. On subsequent days, the recommended dose is 200 mg twice daily as
needed (these doses are only generalizations; doses may vary depending
on the patient's medical history).
Free yourself
from arthritic pain, buy Celebrex arthritis pain relief online now
(click here for details).
Should Celebrex be prescribed in individuals with
a history of ulcers?
NSAIDs should be prescribed with extreme caution in patients with a
prior history of ulcer disease or gastrointestinal bleeding. Most
spontaneous reports of fatal GI events are in elderly or debilitated
patients and therefore special care should be taken in treating this
population. To minimize the potential risk for an and who use NSAIDs,
have a greater than 10-fold higher risk for developing a GI bleed than
patients with neither of these risk factors.
In addition to a past history of
ulcer disease, pharmacoepidemiological studies have identified several
other co-therapies or co-morbid conditions that may increase the risk
for GI bleeding such as: treatment with oral corticosteroids, treatment
with anticoagulants, longer duration of NSAID therapy, smoking,
alcoholism, older age, and poor general health status.
|
