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Fever Blister Information
(detailed information concerning the proper treatment of fever blisters)



The following fever blister information has been compiled from a variety of resources in order to give you an overview of fever blisters so you can understand the mechanism of action behind the most effective fever blister treatment.

A fever blister is a fluid-filled, painful blister which usually occurs on or around the lips. Fever blisters are also known as fever blisters, oral herpes, herpes febrilis, labial herpes and herpes labialis. Fever blisters most often occur on the external lips which distinguishes them from the common canker sore which is usually found inside the mouth.

Fever blisters are caused by the herpes virus. There are some eight different types of human herpes viruses. However, only two of these viruses, herpes simplex, types 1 and 2, cause fever blisters. Common belief is that herpes simplex virus type 1 infects above the waist and herpes simplex virus type 2 infects below the waist. However, this is not always the case both herpes virus type 1 and type 2 can cause herpes lesions on the lips or genitals. However, recurrent fever blisters are almost always a result of the herpes virus type 1.

Unfortunately, oral herpes is very common. Some 80% of the population has had a fever blister while almost 25% of those infected will experience recurrent outbreaks. Individuals can become infected by herpes virus and the virus may remain latent for life or the virus may promote frequent recurrent fever blisters. The highest risk for spreading the virus is the time period beginning with the appearance of the ulcers or blisters. However, infected individuals do not need not have visible ulcers to spread the infection. In addition, the virus may be present in the saliva of infected individuals without obvious oral lesions.

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Viruses are not the same as bacteria. Bacteria are independent cells and can reproduce without the assistance from their host. While, viruses enter their host cells and use the host to replicate the virus. The infected host cell is subsequently killed while the virus is released. For example, in the case of fever blisters the actual ulcer is formed from the death of the cells and the immune response against the virus. The virus can also remain dormant for weeks or even years until some event triggers the virus to become active.

Fever blisters usually are located on the outside surface of the lips, nose, cheeks, chin or possible near the eyes. The lesions are characterized by a prodrome period or the period before a lesion appears when an individual experiences fever, irritability, headaches and a tingling and/or itching in the area where the lesion will appear. A day or so following the initial prodrome period the area will become red and inflamed followed by the appearance of one or more blisters usually found in clusters. These blisters soon erupt resulting in the release of the virus and a grey colored ulcer. The ulcer will eventually crust over and dry up usually without resulting in scare tissue

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Additional Fever Blister Information

What do fever blisters look like?

The following represent common lesions associated with fever blisters:

Fever blisters usually are located on the outside surface of the lips, nose, cheeks, chin or possible near the eyes. The lesions are characterized by a prodrome period or the period before a lesion appears when an individual experiences fever, irritability, headaches and a tingling and/or itching in the area where the lesion will appear. A day or so following the initial prodrome period the area will become red and inflamed followed by the appearance of one or more blisters usually found in clusters. These blisters soon erupt resulting in the release of the virus and a grey colored ulcer. The ulcer will eventually crust over and dry up usually without resulting in scare tissue. View descriptive pictures of fever blisters (click here for details)

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What are the different developmental stages of a fever blister?

The development of a fever blister has several stages:

  • Prodrome stage - the period before a lesion appears when the skin tingles and itches.
     
  • Blister stage - a small patch of skin raises and forms a blister.
     
  • Weeping stage - the blister bursts to form a weeping sore.
     
  • Scab stage - natural healing occurs at the site of the sore.

 


What are the different cycles involved in the life of the virus responsible for fever blisters?

Viruses react in cycles, the initial infection is called the "primary" infection which is followed by a "latent" period. Future outbreaks are called "recurrent" infections.


What is the difference between a fever blister and a canker sore?

Fever Blisters

Fever blisters are viral in origin, they are a result of the herpes virus. Prior to getting fever blisters individuals usually experience a "prodrome" or felling that they are going to get a fever blister prior to the fever blister actually appearing. Often individuals will notice a burning or itching sensation in the region prior to the actual appearance of the fever blister.

Fever blisters are generally smaller than canker sores and typically form on the outside of an individuals mouth, lips or nose. Fever blisters usually form blisters that subsequently break and the weep fluid that is full of virus particles. This virus infected fluid is very contagious, any breaks in the skin or tissue surface is subject to infection by the virus. This is how the virus is spread to different areas of the body.

Canker sores

Canker sores are not viral in origin and they generally erupt inside the mouth on the soft tissue of the lips, cheeks, under the tongue, back of the throat, etc. The origin of canker sores is unknown, there does not seem to be one type of bacteria or virus that seems to be behind an outbreak. Some researchers believe that there may be an auto immune response involved in the presentation of canker sores. Canker sores are also associated with trauma to an area e.g. biting one's tongue, lip, etc. Canker sores are also associated with stress, fatigue, or immune compromise.


Why do I keep having a recurrence of fever blisters?

Unfortunately, after an individual is infected with herpes simplex virus, the virus remains dormant in the nerve root until certain conditions allow another outbreak.

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What triggers the fever blister outbreak?

Clinical studies have shown the following to be significant in the occurrence of outbreaks of fever blisters:

  • Fatigue
  • Stress
  • Common cold
  • Reduction in the immune system
  • Excessive heat or cold
  • Menstruation
  • Fever
  • Trauma or injury including shaving or dental work
  • Sun exposure
 

Are fever blisters contagious?

Yes, fever blisters are the result of the herpes simplex virus which is very contagious. The highest risk for spreading the virus is the time period beginning with the appearance of the ulcers or blisters. However, infected individuals do not need not have visible ulcers to spread the infection.


What prescription medications are available for the treatment of fever blisters?

Valtrex is the first and only oral one-day treatment for fever blisters. The recommended dose is 2 grams taken at the first sign of a fever blister, such as tingling, itching, or burning and then again, approximately 12 hours later.  Individuals should be prepared for subsequent outbreaks of fever blisters by having a supply of Valtrex. Order Valtrex online, (click here for details).


How Common are fever blisters?

Some studies indicate that some eighty percent of the adult population has the herpes simplex I virus that is primarily responsible for fever blisters. A smaller percentage of the individuals that have the virus actually experience recurrent episodes of fever blisters.

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Where do most fever blisters outbreaks occur?

Approximately 95% of the patients with fever blisters, the blisters occur at the outer edge of the lips which is called the "vermilion border." Lesions can also form on the nose, chin or cheek.

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How many outbreaks of fever blisters can an individual expect?

Most individuals experience fewer than three recurrent outbreaks of fever blisters each year. In most individuals, the blisters form in the same area each time and are triggered by the same factors (such as stress, sun exposure, immune compromise, etc.).

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