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First Two-Year Clinical Data For Reductil Slimming Pills Demonstrates Efficacy in Helping Overweight People Maintain Long-Term* Weight Loss.
PR Newswire
June 4, 2009

Growing the Market for Anti-Obesity Drugs
Chemical Marketer Reporter
July 15, 2009

Reductil Evaluated for Weight Maintenance
Psychopharmacology Update
October, 2009

Missing Link Can Help Europeans Control Their Weight
PR Newswire
July 17, 2009

Prescription Appetite Suppressants Bring New Hope to Dieters
Drug Store News
September 12, 2009

First Two-Year Clinical Data For Reductil Demonstrates Efficacy in Helping Overweight  People Maintain Long-Term* Weight Loss.
PR Newswire
June 4, 2009

Results from the second phase of the STORM study -- Reductil Trial in Obesity Reduction and Maintenance -- released today at the European Congress on Obesity in Milan suggest that Reductil slimming pills are effective in helping most people maintain initial six month weight loss for up to two years. According to the study, 87 percent of people taking Reductil maintained more than a eighty percent weight loss (compared to 10 percent in placebo (sugar pill) group) and 87 percent maintained more than a ninety percent weight loss (compared to 11 percent in the placebo group).

"There was a significant difference between the Reductil and a placebo in the STORM study that has important clinical benefits," remarked Arne Astrup, M.D., Ph.D., STORM investigator and professor of human nutrition at the Royal Veterinary and Agricultural University of Denmark.

For many people, maintaining weight loss is a difficult task. According to Kelly Brownell, Ph.D., director of the Yale Center for Eating and Weight Disorders at Yale University in New Haven, Conn., "Maintenance is essential for realizing the health and psychological benefits of initial weight loss. Without the right tools, regain of lost weight can be an all too common experience."

Reductil works by affecting chemicals in the brain involved in regulating appetite and helps people overcome one of the biggest barriers to losing weight, because it helps them feel full so they can eat less -- a feeling also known as satiety.

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Clinical studies with Reductil have shown Reductil to be a well tolerated, safe and effective weight management medication with the majority of people losing between twenty and thirty percent of their body weight. Early findings from the STORM study appear to reconfirm previous studies showing weight loss and maintenance of weight loss.

Professor Astrup added, "These interim STORM results show that these Reductil slimming pills are much more effective than we had hoped."

About Reductil Slimming Pills

Reductil is indicated for the management of overweight individuals, including weight loss and maintenance of weight loss when used in conjunction with a reduced-calorie diet. Reductil is recommended for patients with an initial BMI (body mass index -- weight in kilograms divided by height in meters squared) greater than or equal to 30 kg/m(squared) or greater than or equal to 27 kg/m(squared) in the presence of other risk factors (e.g., hypertension, diabetes, dyslipidemia). Reductil is taken once a day without regard to meals.

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Growing the Market for Anti-Obesity Drugs
Chemical Marketer Reporter
July 15, 2009

The anti-obesity drug market has seen a major upswing in growth during the past year as new drugs entered the marketplace, offering fresh alternatives for drug-assisted weight loss. With the introduction of Knoll's Reductil (sibutramine) in 1998 and the more recent approval of Roche's Xenical (orlistat) in April 1999, the market has grown 70 percent in just one year.

However the entry of Reductil and Xenical may turn this around. The US market for prescription anti-obesity drugs tallied $321 million in 1999, according to IMS Health. While representing a small portion of the overall drug market, this segment has grown substantially over the previous year where the market was reported at $188 million. The dramatic shift can be attributed to the introduction of two new drugs--Roche's Xenical and Meridia, made by the Knoll Pharmaceuticals, the pharmaceutical unit of BASF.

Competing directly with Xenical in the diet drug market is Knoll's Reductil. Reductil, a reuptake inhibitor functions on the brain to control hunger by inhibiting the reuptake of the neurotrausmitter norepinephrine and seratonin. Reductil functions differently than the diet drug phentermine, which, besides preventing the reuptake of seratonin, acts to increase the release of seratonin into the brain, explains a Knoll official.

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Reductil sales exceeded $125 million, according to IMS Health.T One of the keys to market penetration in the anti-obesity drug market is to build consumer awareness of the need for such drugs. Currently only 10 percent of the population considered at health risk due to obesity are on prescription treatment. "The challenge is to get the information out to the public," the BASF official. "By advertising through television and magazines, patients are learning about these drug options first hand and are going to their physicians, requesting medication for obesity, rather than relying on the physician to broach what could be a delicate topic." Knoll Pharmaceutical was the first to use direct-to-consumer marketing for Reductil.

Health care providers too are beginning to realize the need for drug treatment to help combat obesity, Last year, only 30 percent of healthcare providers covered prescription drugs for obesity, but there are now at least 36 percent that do so. In the past obesity was considered a social issue, related to a lack of willpower and exercise. More and more, obesity is being recognizing as a serious, life-threatening disease. Some observers even term obesity an epidemic.

Reductil remains one of the most promising slimming pills available in Europe. Numerous clinical trials continue to show that individuals lose 2-3 times more weight when they combine Reductil in their healthy diet plan.

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Reductil Evaluated for Weight Maintenance
Psychopharmacology Update
October, 2009

Investigators conducted a randomized, double-blind trial to assess the usefulness of Reductil in maintaining substantial weight loss over two years.

Eight European centers recruited 2605 obese patients Patients received 15 mg of Reductil for six months and followed an individualized 600 calorie-per-day deficit program based on their resting metabolic rates. Then, 87% of patients with more than a 5 percent weight loss were randomly assigned to received 15mg daily of Reductil (or placebo (sugar pill) for 18 months further. The dose of Reductil was increased up to 20 mg daily if weight regain occurred.

The primary outcome measure of the study was the number of patients at year two who had maintained at least 90 percent of the weight loss between baseline and month six.

Of patients on Reductil who completed the study, 83% maintained 90 percent or more of their original weight loss compared with 16% of the patients in the placebo group (sugar pill).

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In addition, patients had substantial decreases in triglyceride, cholesterol, insulin, uric acid and other levels, which were sustained in the Reductil group but not the placebo group.

The individualized management program achieved weight loss in 87 percent of over weight patients sustained weight loss in most patients continuing therapy for two years," Therefore Reductil is very helpful in allowing individuals to lose their initial weight and to keep the weight off, the authors concluded.

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Reductil significantly promoted earl weight loss in the treatment and then more importantly some 87 percent of individuals kept the weight that they initially lost for up to 2 full years. This is such promising news for those individuals trying to lose weight.

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Missing Link Can Help European Control Their Weight
PR Newswire
July 17, 2007Experts Convene to Discuss New Survey Results, Importance of Brain and Stomach Connection When It Comes to Eating and the Role of Medication in Facilitating This Connection Europeans do not clearly understand the essential role that satiety -- feeling full when eating -- plays in weight management, according to national experts who convened in New York City to analyze results from a nationwide survey, the Weight Expectations Report. These experts in the behavioral and clinical practice of weight management concluded that learning to recognize and respond to feelings of fullness, or satiety cues, is a missing link in enabling people to control their weight. "One of the most interesting findings from this survey is the link between satiety, control of one's weight and the feeling of control over one's life. If we can use satiety to help people understand how to gain control of their food intake and ultimately their weight, the repercussions for health -- both physical and emotional -- are significant," said Kelly Brownell, Ph.D., director of the Yale University Center for Eating and Weight Disorders, New Haven, Conn. and moderator of the roundtable. "Our society is bombarded with an over abundant supply of high-calorie, high fat foods which makes the enhancement of satiety that much more important," added Dr. Brownell.

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 Key Finding to Weight Loss: Satiety, Control and Self-Image According to the report, only 25 percent of Europeans achieve satiety "all of the time" when they eat, 44 percent achieve it "some of the time" and nearly three out of 10 "hardly ever" achieve satiety. Moreover, nearly half (47%) of people who experience feelings of fullness continue eating, overriding their "little voice" known as satiety. Respondents who "hardly ever" experience satiety, and continue to eat after feeling full, believed they had much more weight to lose than those that consistently responded to feelings of fullness (27 pounds versus 13 pounds). Conversely, people who were able to control their weight had a more positive self-image. On average, men had a more positive self-image than women.

Specifically, at least three out of five respondents who described themselves as being in control of their weight see themselves as:

1. Self-motivated in attaining financial security 81% Possessing high self-esteem 81% Possessing a positive body image 80% Self-motivated in a career path 76%
2. Self-motivated in a physical exercise program 60%

Key Finding: Satisfaction with Weight Loss Strategy Teaching people how to relearn satiety is a key strategy in a successful weight-management program, but one of the most difficult to implement. Weight loss strategies vary and can include increasing physical activity, reducing calorie intake, eating smaller portions, taking prescription weight-loss medication, as well as restricting fats, sugar or carbohydrates from the diet.

"All too often, Europeans are looking for a quick fix, like eliminating fats or carbohydrates completely from their diet. People need to learn that eating a variety of portion-controlled foods without eliminating any one dietary component is the way to support healthy weight goals and live a 'real' life," emphasized Cathy Nonas, M.S., R.D., a registered dietician at the Theodore B. Van Itallie Center for Nutrition and Weight Management at St. Lukes-Roosevelt Hospital in New York, N.Y., and a participant in the roundtable. *

In the past year, four-fifths (80%) of Europeans said they tried at least one weight loss strategy. People who used at least one strategy tried an average of four strategies during that time period. Key Finding: Role of Reductil Slimming Pills  in Satiety "Some of my patients do not receive the 'I feel full' message. In such instances, I feel it is helpful to them to prescribe medication that affects the appetite control center in the brain to help them reestablish that connection," noted Peter Vash, M.D., assistant professor at UCLA Medical Center iwho regularly counsels patients on weight management and a roundtable contributor.

According to Maria Jenkins, a person taking Reductil and a roundtable participant, "I tried eliminating fats from my diet but I still wasn't reducing the amount of food I ate so I was not losing weight. With the help of Reductil, I am able to recognize when I feel full and eat less. Feeling satisfied with less food has helped me regain control of my weight and my life."

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Ms. Nonas added that, "Learning to eat less and listening to your 'little voice' in an environment that tells us to eat more is not easy. A low-calorie diet and increased physical activity, and in some cases medication, are an essential part of that learning process for my patients." Dr. Vash confirmed that, "With Reductil, my patients now have a safe, effective and well tolerated option to help them gain control over their eating habits. However, no medication is a magic bullet for weight loss -- my patients understand they have to do their part with diet and exercise."

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Prescription Appetite Suppressants Bring New Hope to Dieters
Drug Store News
September12, 2007Obesity is a serious medical condition with high health risks, contributing to a myriad of other health problems, such as atherosclerosis, hypertension, coronary heart disease, dyslipidemias and diabetes mellitus, to name only a few. Weight loss of only a few pounds can significantly reduce the health risks associated with any such disease state to improve both the prognosis and quality of life for successful patients. Reductilt represent what is considered to be some real progress toward developing appetite suppressants that are actually safe and effective. Their mechanisms of action differ markedly from their marketed predecessors. Reductil Slimming PillsRather than increase production of serotonin like Redux, Reductil  is a monoamine repute inhibitor that effectively increases levels of both serotonin and noradrenaline by retarding their normal removal from the sites of action. . The higher levels of these neurotransmitters have been shown to both increase metabolic rate and reduce appetite, a very effective combination for weight reduction, especially in conjunction with a carefully managed program of exercise, diet and behavior modification.

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Reductil has little effect on monoamine oxidase but blocks reuptake of dopamine to some extent, in addition to its effects on serotonin and noradrenaline. Available in 5-mg, 10-mg and 15-mg capsules, initial recommended dose is 15 mg daily without regard to meals, with an increase to 15 mg daily for unresponsive patients.

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