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First Two-Year Clinical Data For Reductil
Slimming Pills Demonstrates Efficacy in Helping Overweight
People Maintain Long-Term* Weight Loss.
PR Newswire
November 4, 2007
Growing the Market for Anti-Obesity Drugs
Chemical Marketer Reporter
May 15, 2007
Reductil
Evaluated for Weight Maintenance
Psychopharmacology Update
February, 2008
Missing Link Can Help Europeans Control
Their Weight
PR Newswire
May 17, 2007
Prescription
Appetite Suppressants Bring New Hope to Dieters
Drug Store News
January 12, 2008
First Two-Year Clinical Data For
Reductil
Demonstrates Efficacy in Helping
Overweight People Maintain Long-Term*
Weight
Loss
PR Newswire
November 4, 2007
Results from the second phase of the STORM
study -- Reductil Trial in Obesity Reduction and Maintenance --
released today at the European Congress on Obesity in Milan
suggest that Reductil slimming pills are effective in helping
most people maintain initial six month
weight loss for up to two years.
According to the study, 87 percent of people taking Reductil
maintained more than a eighty percent weight loss (compared to
10 percent in placebo (sugar pill) group) and 87 percent
maintained more than a ninety percent
weight loss
(compared to 11 percent in the placebo group).
"There was a significant difference between
the Reductil and a placebo in the STORM study that has important
clinical benefits," remarked Arne Astrup, M.D., Ph.D., STORM
investigator and professor of human nutrition at the Royal
Veterinary and Agricultural University of Denmark.
For many people, maintaining
weight loss is a difficult task.
According to Kelly Brownell, Ph.D., director of the Yale Center
for Eating and Weight Disorders at Yale University in New Haven,
Conn., "Maintenance is essential for realizing the health and
psychological benefits of initial
weight loss. Without the right
tools, regain of lost weight can be an all too common
experience."
Reductil
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appetite and helps people overcome one of the biggest barriers
to losing weight, because it helps them feel full so they can
eat less -- a feeling also known as satiety.
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Clinical studies with
Reductil have shown Reductil to
be a well tolerated, safe and effective weight management
medication with the majority of people losing between twenty and
thirty percent of their body weight. Early findings from the
STORM study appear to reconfirm previous studies showing weight
loss and maintenance of
weight loss.
Professor Astrup added, "These interim
STORM results show that these Reductil slimming pills are much
more effective than we had hoped."
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About
Reductil
Reductil is indicated for the management of
overweight individuals, including weight loss and maintenance of
weight loss when used in
conjunction with a reduced-calorie diet. Reductil is recommended
for patients with an initial BMI (body mass index -- weight in
kilograms divided by height in meters squared) greater than or
equal to 30 kg/m(squared) or greater than or equal to 27
kg/m(squared) in the presence of other risk factors (e.g.,
hypertension, diabetes, dyslipidemia). Reductil is taken once a
day without regard to meals.
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Growing the Market for Anti-Obesity
Drugs
Chemical Marketer Reporter
May 15, 2007
The anti-obesity drug market has seen a
major upswing in growth during the past year as new drugs
entered the marketplace, offering fresh alternatives for
drug-assisted
weight loss.
With the introduction of Knoll's Reductil (sibutramine) in 1998
and the more recent approval of Roche's
Xenical
(orlistat) in April 1999, the market has grown 70 percent in
just one year.
However the entry of Reductil and
Xenical
may turn this around. The US market
for prescription anti-obesity drugs tallied 321 million in 1999,
according to IMS Health. While representing a small portion of
the overall drug market, this segment has grown substantially
over the previous year where the market was reported at 188
million. The dramatic shift can be attributed to the
introduction of two new drugs--Roche's
Xenical
and
Reductil, made by the
Knoll Pharmaceuticals, the pharmaceutical unit of BASF.
Competing directly with
Xenical in the diet drug market
is Knoll's Reductil. Reductil, a reuptake inhibitor functions on
the brain to control hunger by inhibiting the reuptake of the
neurotrausmitter norepinephrine and seratonin. Reductil
functions differently than the diet drug phentermine, which,
besides preventing the reuptake of seratonin, acts to increase
the release of seratonin into the brain, explains a Knoll
official.
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Reductil saw sales of 125 million, according
to IMS Health.T One of the keys to market penetration in the
anti-obesity drug market is to build consumer awareness of the
need for such drugs. Currently only 10 percent of the population
considered at health risk due to obesity are on prescription
treatment. "The challenge is to get the information out to the
public," the BASF official. "By advertising through television
and magazines, patients are learning about these drug options
first hand and are going to their physicians, requesting
medication for obesity, rather than relying on the physician to
broach what could be a delicate topic." Knoll Pharmaceutical was
the first to use direct-to-consumer marketing for
Reductil.
Health care providers too are beginning to
realize the need for drug treatment to help combat obesity, Last
year, only 30 percent of healthcare providers covered
prescription drugs for obesity, but there are now at least 36
percent that do so. In the past obesity was considered a social
issue, related to a lack of willpower and exercise. More and
more, obesity is being recognizing as a serious,
life-threatening disease. Some observers even term obesity an
epidemic.
Reductil
remains one of the
most promising slimming pills available in Europe. Numerous
clinical trials continue to show that individuals lose 2-3 times
more weight when they combine Reductil in their healthy diet
plan.
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Reductil Evaluated for Weight Maintenance
Psychopharmacology Update
February, 2008
Investigators conducted a randomized,
double-blind trial to assess the usefulness of Reductil in
maintaining substantial weight loss over two years.
Eight European centers recruited 2605 obese
patients Patients received 15 mg of Reductil for six months and
followed an individualized 600 calorie-per-day deficit program
based on their resting metabolic rates. Then, 87% of patients
with more than a 5 percent weight loss were randomly assigned to
received 15mg daily of Reductil (or placebo (sugar pill) for 18
months further. The dose of Reductil was increased up to 20 mg
daily if weight regain occurred.
The primary outcome measure of the study
was the number of patients at year two who had maintained at
least 90 percent of the weight loss between baseline and month
six.
Of patients on Reductil who completed
the study, 83% maintained 90 percent or more of their original
weight loss compared with 16% of the patients in the placebo
group (sugar pill).
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In addition, patients had substantial
decreases in triglyceride, cholesterol, insulin, uric acid and
other levels, which were sustained in the
Reductil group but not the
placebo group.
The individualized management program
achieved weight loss in 87 percent of over weight patients
sustained weight loss in most patients continuing therapy for
two years," Therefore
Reductil
is very helpful in
allowing individuals to lose their initial weight and to keep
the weight off, the authors concluded.
Reductil Weight Loss Conclusion,
Reductil significantly promoted earl weight loss in the treatment
and then more importantly some 87 percent of individuals kept
the weight that they initially lost for up to 2 full years. This
is such promising news for those individuals trying to lose
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Missing Link Can Help European
Control Their Weight
PR Newswire
May 17, 2007
Experts Convene to Discuss New Survey
Results, Importance of Brain and Stomach Connection When It
Comes to Eating and the Role of Medication in Facilitating
This Connection
Europeans do not clearly understand the
essential role that satiety -- feeling full when eating -- plays
in weight management, according to national experts who convened
in London to analyze results from a nationwide survey, the
Weight Expectations Report. These experts in the behavioral and
clinical practice of weight management concluded that learning
to recognize and respond to feelings of fullness, or satiety
cues, is a missing link in enabling people to control their
weight.
"One of the most interesting findings
from this survey is the link between satiety, control of one's
weight and the feeling of control over one's life. If we can use
satiety to help people understand how to gain control of their
food intake and ultimately their weight, the repercussions for
health -- both physical and emotional -- are significant," said
Kelly Brownell, Ph.D., director of the Yale University Center
for Eating and Weight Disorders, New Haven, Conn. and moderator
of the roundtable.
"Our society is bombarded with an over
abundant supply of high-calorie, high fat foods which makes the
enhancement of satiety that much more important," added Dr.
Brownell.
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Key Finding: Satiety, Control and
Self-Image
According to the report, only 25 percent of
Europeans achieve satiety "all of the time" when they eat, 44
percent achieve it "some of the time" and nearly three out of 10
"hardly ever" achieve satiety. Moreover, nearly half (47%) of
people who experience feelings of fullness continue eating,
overriding their "little voice" known as satiety.
Respondents who "hardly ever" experience
satiety, and continue to eat after feeling full, believed they
had much more weight to lose than those that consistently
responded to feelings of fullness (27 pounds versus 13 pounds).
Conversely, people who were able to control their weight had a
more positive self-image. On average, men had a more positive
self-image than women.
Specifically, at least three out of five
respondents who described themselves as being in control of
their weight see themselves as:
- Self-motivated in attaining financial
security 81%
- Possessing high self-esteem
81%
- Possessing a positive body image
80%
- Self-motivated in a career path
76%
- Self-motivated in a physical exercise
program 60%
Key Finding: Satisfaction with Weight
Loss Strategy
Teaching people how to relearn satiety is a
key strategy in a successful weight-management program, but one
of the most difficult to implement. Weight loss strategies vary
and can include increasing physical activity, reducing calorie
intake, eating smaller portions, taking prescription weight-loss
medication, as well as restricting fats, sugar or carbohydrates
from the diet.
"All too often, Europeans are looking for
a quick fix, like eliminating fats or carbohydrates completely
from their diet. People need to learn that eating a variety of
portion-controlled foods without eliminating any one dietary
component is the way to support healthy weight goals and live a
'real' life," emphasized Cathy Nonas, M.S., R.D., a registered
dietician at the Theodore B. Van Itallie Center for Nutrition
and Weight Management at St. Lukes-Roosevelt Hospital in New
York, N.Y., and a participant in the roundtable.
* In the past year, four-fifths (80%) of
Europeans said they tried at least one
weight loss strategy. People who
used at least one strategy tried an average of four strategies
during that time period.
Key Finding: Role of
Reductil
Slimming Pills
in Satiety
"Some of my patients do not receive the 'I
feel full' message. In such instances, I feel it is helpful to
them to prescribe medication that affects the appetite control
center in the brain to help them reestablish that connection,"
noted Peter Vash, M.D., assistant professor at UCLA Medical
Center iwho regularly counsels patients on weight management and
a roundtable contributor.
According to Maria Jenkins, a person
taking Reductil and a roundtable participant, "I tried
eliminating fats from my diet but I still wasn't reducing the
amount of food I ate so I was not losing weight. With the help
of Reductil, I am able to recognize when I feel full and eat
less. Feeling satisfied with less food has helped me regain
control of my weight and my life."
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Ms. Nonas added that, "Learning to eat
less and listening to your 'little voice' in an environment that
tells us to eat more is not easy. A low-calorie diet and
increased physical activity, and in some cases medication, are
an essential part of that learning process for my patients."
Dr. Vash confirmed that, "With
Reductil,
my patients now have a safe, effective and well tolerated option
to help them gain control over their eating habits. However, no
medication is a magic bullet for weight loss -- my patients
understand they have to do their part with diet and exercise."
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Prescription Appetite Suppressants
Bring New Hope to Dieters
Drug Store News
January 12, 2008
Obesity is a serious medical condition with
high health risks, contributing to a myriad of other health
problems, such as atherosclerosis, hypertension, coronary heart
disease, dyslipidemias and diabetes mellitus, to name only a
few. Weight loss of only a few pounds can significantly
reduce the health risks associated with any such disease state
to improve both the prognosis and quality of life for successful
patients.
Reductilt represent what is considered to be
some real progress toward developing appetite suppressants that
are actually safe and effective. Their mechanisms of action
differ markedly from their marketed predecessors.
Reductil Slimming Pills
Rather than increase production of
serotonin like Redux,
Reductil is a monoamine repute
inhibitor that effectively increases levels of both serotonin
and noradrenaline by retarding their normal removal from the
sites of action. . The higher levels of these neurotransmitters
have been shown to both increase metabolic rate and reduce
appetite, a very effective combination for weight reduction,
especially in conjunction with a carefully managed program of
exercise, diet and behavior modification.
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Reductil has little effect on monoamine
oxidase but blocks reuptake of dopamine to some extent, in
addition to its effects on serotonin and noradrenaline.
Available in 5-mg, 10-mg and 15-mg capsules, initial recommended
dose is 15 mg daily without regard to meals, with an increase to
15 mg daily for unresponsive patients.
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