Xenical Information
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Xenical
weight loss pills represent the only prescription fat blocker. Xenical
is a prescription fat blocker that blocks one third of of the calories
from fat from being utilized.
This is very significant especially when
one notes that each gram of fat consists of nine calories, as compared,
to one gram of protein or carbohydrates which account for only four
calories.
This fat blocking mode enables you to lose weight fast while
still enjoying some of the foods in your diet that you like to eat.
Xenical
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The following Xenical
information has been compiled from a variety of resources in order to
give you an idea of just how Xenical has helped so many individuals lose
weight fast.
Why do so many doctors recommend Xenical to their patients who
want to safely lose weight?
Xenical represents one of the safest weight loss
medications. Xenical has been extensively tested throughout Europe, as
well as, in the United States. Distinct from other medicines that
stimulate the brain to suppress the appetite, Xenical uses a fat
blocking mode of action that works non-systematically in the
gastrointestinal tract.
The end result is approximately 33 percent of dietary fat passes
through the body undigested. Therefore, Xenical blocks some 33% of the
calories from fat from being absorbed. This allows you to consume
less calories and
lose weight.
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Why is Xenical sometimes referred to as
orlistat?
Orlistat is the generic name for Xenical. The
generic name represents the medications nonproprietary or chemical name,
whereas, the brand name is the name a pharmaceutical give to a
medication for marketing purposes.
How does Xenical work?
Distinct from other medications that effect
neurotransmitters to stimulate the brain to suppress your appetite.
Xenical uses a fat blocking mode of action that works non-systemically
in the gastrointestinal tract. Dietary fats are large molecules that
must be broken down by enzymes, called lipases, before they can be
absorbed into the bloodstream. Xenical interferes with these lipases
by forming covalent bonds with the them in the stomach and small
intestine, this essentially inactivates the enzymes so they are no
longer available to hydrolyze dietary fat into an absorbable state.
Thus, allowing for some 33 percent of dietary fats to pass through the
gastrointestinal tract unchanged. *Xenical works here, covalently
bonding to the pancreatic lipases
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What clinical studies have been completed with
regards to Xenical's ability to promote fast weight loss?
Xenical was evaluated in a placebo-controlled
(sugar pill), double blind study to examine the effectiveness of a
medication for weight loss and the prevention of weight regain over a
two-year period.
During the first year, participants who met the
definition of overweight were placed on a low calorie diet while
randomly given a placebo or Xenical. Research following the first year
indicated those individuals treated with Xenical (120 mg per dose) lost
approximately three times more weight than the control (placebo) group.
In the second year, participants were placed on
a weight maintenance diet and the Xenical group was randomized to
receive either a placebo or different doses of Xenical. Results
following the second year indicated the individuals on orlistat, 120 mg
per dose, three times per day were two times as likely to keep the
weight off as those individuals in the control (placebo) group.
"This study demonstrates that partial
inhibition of fat absorption in obese subjects can produce sustained
weight loss," the authors conclude. "Subjects treated with Xenical plus
a mildly controlled-energy diet lost significantly more weight than
those treated with placebo plus diet even though all subjects received a
high standard of care and similar dietary counseling…These observations
collectively suggest that Xenical may be a useful adjunct to dietary
intervention in producing and maintaining weight loss over two years."
Journal of the Medical Association (JAMA. 1999;281:235-242)
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Recent study in Switzerland revealed the
following:
Basel, Switzerland -- The
weight loss medication Xenical helps
patients achieve rapid and sustained weight loss according to the
results of a new study designed to reflect real world usage of Xenical
in clinical practice.(1)
The 12 month study of 430 overweight men and women
was designed to assess the effectiveness of Xenical in patients who are
responsive to treatment. Patients who achieved 9 per cent (approximately
8kg) weight loss after 3 months and maintained this after a further 3
months of Xenical treatment, were followed for one year.
During this time weight loss and other health improvements, such as
reductions in blood pressure, were assessed.
The results suggest that the efficacy of Xenical in a real-life
clinical practice setting is even greater than that demonstrated
previously in clinical trials:
- The greatest weight loss was seen in the
first four weeks of treatment, with an average weight loss of 7.1 kg
- Three out of four people achieved 10 per
cent weight loss by month three, losing an average of 10.6 kg
- By month four 15 per cent of these people
had maintained at least 6 percent weight loss, with an average
weight loss of 12.9kg.
- The average weight loss after one year was
17.6 kg. One in two patients in the study lost more than 13 per cent
of their initial weight, and over 8 in ten people lost more than 8
per cent -- an amount of weight loss shown to clinically improve the
health and well-being of overweight people.
Commenting on the results, lead study
investigator Professor Hermann Toplak from the
Karl-Franzens-Universitat, Graz, Austria said, "These results
demonstrate the significant benefits of rapid and continuous weight loss
with Xenical in a clinical practice setting.
Patients who respond rapidly to treatment continue
with treatment and achieve long-term weight loss success."
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Are there any other benefits to taking
Xenical other than weight reduction?
Yes, studies have shown that even a modest
weight loss as a result of Xenical and diet can significantly reduce the
following life-risk factors:
- Reduction of blood glucose levels
(decreasing the risk of diabetes).
- Lowering of diastolic and systolic blood
pressure (decreasing the risk of heart disease and strokes).
- Reduction in blood cholesterol levels
(decreasing the risk of heart disease and strokes).
- Reduction of blood levels of uric acid
(decreasing the risk of gout).
- Reduction in the cases of sleep apnea
(irregular breathing during sleep).
- Weight reduction is also likely to improve
appearance, which has a positive affect on self-esteem and
motivation.
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What is the appropriate dose of
Xenical?
The recommended dose of Xenical is one 120-mg
capsule taken with each meal that contains fat. Individuals may take
Xenical in combination with a moderately reduced calorie diet up to
three times per day. In the event, a meal is without fat content or a
meal is periodically missed an individual may omit that dose.
Doses in excess of 120 mg three times per day have
not proven to advantageous to weight reduction. For the best results,
individuals should practice eating a well-balanced, moderately reduced
calorie diet that contains no more than 30 percent of the calories from
fat.
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What about missed doses of
Xenical?
If you forget to take your Xenical, you should
take the Xenical immediately when you remember, provided no longer than
an hour has passed since the last meal. Do not double the dose of
Xenical or change the prescribed Xenical dose without the recommendation
of a doctor.
When is it
inappropriate to take Xenical?
Xenical is contradicted
in the following circumstances:
- Individuals who have been
diagnosed with a decreased ability to absorb the essential nutrients
e.g. chronic malabsorption syndrome, tropical sprue, idiopathic
steatorrhea, etc.
- Individuals with
inflammatory bowel disease e.g. Crohn's disease and ulcerative
colitis.
- Individuals with
complications of the bilary tract including the gallbladder.
- Individuals with organic
causes of obesity, such as hypothyroidism.
- Women who are pregnant or
breastfeeding.
- Individuals who have eating
disorders e.g. anorexia, bulimia, etc.
- Individuals who have had
allergic reactions to orlistat or any of the active ingredients in
the medication.
Should Xenical be
taken during pregnancy or while breastfeeding?
The safety of Xenical has not been
established in pregnant women, therefore Xenical should not be used in
women who are trying to get pregnant or in women who are pregnant. Women
should not take Xenical while breastfeeding their infant because it is
not known whether Xenical is excreted in the breast milk.
Does Xenical interact with the use of
birth control pills?
No, there has not been any clinical data to
suggest that Xenical would decrease the effectiveness of birth control
pills. Is Xenical appropriate for pediatric or geriatric populations?
The safety and efficiency of Xenical in the pediatric population have
not been established. In addition, clinical studies concerning Xenical
did not include a sufficient number of elderly individuals age 65 years
and older to determine whether they respond differently from younger
individuals. So at this time pediatric and geriatric populations should
refrain from using Xenical until more studies are completed.
Can I get Xenical over the counter?
No, Xenical is a prescription medication and
should only be taken when prescribed by a licensed doctor. Regulations
do not permit Xenical to be taken without a prescription.
However, secondary to the advent of the
internet individuals can now order lifestyle medication, such as,
Xenical online. Individuals are ask to complete a medical questionnaire
which is subsequently reviewed by a physician, once approved your
Xenical order will be shipped discreetly and promptly to you. This
represent a safe way to order Xenical without the expensive office
visits to your local doctor.
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