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New Data Show Fast and Significant Weight Loss With Xenical Sustained Over Time; 6kg Loss in First Month and Rising to 13.6kg After 1 Year.
PR Newswire
May, 2007

Drug Development, Xenical Fat Blocker, Drug Launched in United Kingdom
World Disease Weekly Plus
October 2007

Study Shows Weight Loss Program With Xenical Can Also Help Lower Blood Pressure in Obese Hypertensive Patients.
PR Newswire
Nov 13, 2007

Rx Fat Blockers, Xenical, Bring New Hope to Dieters
Drug Store News
Jan 12, 2007


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New Data Show Fast and Significant Weight Loss With Xenical Sustained Over Time; 6kg Loss in First Month and Rising to 13.6kg After 1 Year.
PR Newswire
May 28, 200
7

BASEL, Switzerland -- The weight loss medication Xenical helps patients achieve rapid and sustained weight loss according to the results of a new study designed to reflect real world usage of Xenical in clinical practice.

The 12 month study of 1430 overweight men and women, was designed to assess the effectiveness of Xenical in patients who are responsive to treatment. Patients who achieved 5 per cent (approximately 6kg) weight loss after 3 months and maintained this after a further 3 months of Xenical treatment, were followed for one year. During this time weight loss and other health improvements, such as reductions in blood pressure, were assessed. The results suggest that the efficacy of Xenical in a real-life clinical practice setting is even greater than that demonstrated previously in clinical trials:

-- The greatest weight loss was seen in the first four weeks of treatment, with an average weight loss of 6.1 kg

-- Three out of four people achieved 5 per cent weight loss by month three, losing an average of 13kg

-- By month 6, 92 per cent of these people had maintained at least 80 per cent weight loss, with an average weight loss of 10.9kg.

-- The average weight loss after one year was 14.6 kg. One in two patients in the study lost more than 10 per cent of their initial weight, and over 8 in ten people lost more than 5 per cent -- an amount of weight loss shown to clinically improve the health and well-being of overweight people.

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Commenting on the results, lead study investigator Professor Hermann Toplak from the Karl-Franzens-Universitat, Graz, Austria said, "These results demonstrate the significant benefits of rapid and continuous weight loss with Xenical in a clinical practice setting. Patients who respond rapidly to treatment continue with treatment and achieve long-term success."

Results also demonstrated significant health gains associated with weight loss with Xenical. Specifically, people treated with Xenical achieved improvements in:

-- Waist circumference: An average reduction of 10.8 cm was achieved after one year. Excess fat around the waist is associated with insulin resistance, high blood sugar, high cholesterol levels and high blood pressure

-- Blood pressure: In patients with hypertension, mean systolic and diastolic blood pressure were reduced by 18.1mmHg and 9.9mmHg respectively

-- Cholesterol: The lipid profile of patients was markedly improved: mean LDL-cholesterol ('bad' cholesterol) levels were reduced by 10.7 per cent and mean total cholesterol levels by 6.8 per cent

The reductions in blood pressure are a key finding as the number of overweight people with hypertension is almost three times higher than the number of adults with a healthy weight.(3) Xenical is the only prescription weight-loss medication, which can be used in patients with hypertension or uncontrolled hypertension.(4)

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Xenical's mode of action is unique. Unlike appetite suppressants, which have a history of withdrawals because of safety concerns, Xenical does not act on the central nervous system. As a result of Xenical's non-systemic mode of action, it has a safety and tolerability profile, which makes it appropriate for use in a wide range of people. This is particularly important within the area of overweight / obesity, where a significant number of people suffer from, or are at risk of cardiovascular disease.

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Drug Development, Xenical Fat Blocker Drug, Launched in United Kingdom
World Disease Weekly Plus

October 2007

Doctors said a two-year clinical trial showed that Xenical, plus a reduced fat diet, helped obese people lose more than 15percent of their body weight in less than 2 months

"Xenical produces and maintains clinically significant weight loss," Dr. Nick Finer, a consultant endocrinologist, told a news conference to launch the treatment.

Unlike slimming pills that suppress the appetite, Swiss drugs giant Roche Holding' "fat blocker" drug is an approach to treating obesity, a condition that affects tens of millions of people worldwide.

Xenical, known generically as orlistat, works in the gut where it prevents absorption of 30 percent of dietary fat. Too much fat in the diet and lack of exercise are the main causes of obesity.

"Obesity is now being recognized as a medical problem. We are now being given the tools to do something useful about it," said Professor Gareth Williams, University of Liverpool, in northwest England. "We have to do this as part of a plan," he added.

People are prescribed the drug only if they are clinically obese and have lost 4.5kg  over four consecutive weeks on a special Medical Action Plan designed as part of the treatment.

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Study Shows Weight Loss Program With Xenical, Can Also Help Lower Blood Pressure in Obese Hypertensive Patients.
PR Newswire
Nov 13, 2007

BIRMINGHAM, Ala.

Results from a multi-center clinical trial headed by researchers  show that weight loss induced by Xenical (orlistat) can significantly reduce elevated blood pressure in overweight people.

The results will be presented today at the European Heart Association's 73rd annual Scientific Sessions.

David Calhoun, M.D., , said the results are of particular importance because persistent obesity often reduces the effect of antihypertensive medications.

The study investigated the effect of Xenical on weight loss and blood pressure in patients with treated but inadequately controlled high blood pressure. Xenical induces weight loss by blocking the absorption of dietary fat.

Calhoun said researchers found that those patients treated with Xenical experienced a significantly greater decrease in diastolic blood pressure compared with placebo and significantly greater weight loss. They also found that a greater percentage of patients who received Xenical obtained a significant blood pressure benefit by reducing their blood pressure to a normal level or by at least 10 points.

"In addition to its favorable effect on blood pressure, weight loss with Xenical was found to produce a significantly greater reduction in cholesterol levels," Calhoun said. Patients taking Xenical experienced a tenfold greater reduction in total cholesterol level compared with placebo, and threefold greater reduction in low-density lipoprotein (LDL) cholesterol. Buildup of cholesterol is the most common cause of coronary heart disease.

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Rx Fat Blockers, Xenical, Bring New Hope to Dieters
Drug Store News

January 12, 2007

Presciption fat blockers, Xenical are helping individuals lose weight fast and maintain this weight loss for long periods of time.

Xenical mechanism of action is very different, interfering with the absorption of fats in the digestive system. Lipids provide more than twice the caloric load of either carbohydrates or proteins, so blocking the utilization of fats for caloric production has obvious advantages.

Long-chain triglycerides account for more than 95 percent of the 50 grams to 120 grams of lipids in the average daily European adult diet, with phospholipids accounting for 2 grams to 4 grams per day and cholesterol accounting for 250 mg to 600 mg per day. These lipid entities must be emulsified, then lipases are essential in the hydrolysis of the fatty acidester linkages to produce more polar molecules to facilitate aqueous dispersion and eventual adsorption in the upper small intestine.

Xenical is the hydrogenated derivative of lipstatin, a naturally occurring lipase inhibitor produced by Streptomyces toxytricini. Undergoing only marginal systemic absorption, it remains primarily in the gut and interferes with the action of pancreatic lipase and carboxylester lipase secreted into the intestine. It reduces triglyceride hydrolysis and subsequent absorption of monoglycerides and free fatty acids.

In less technical terms, Xenical weight loss pills, block 1/3 of the calories consumed in your diet from being absorbed. Therefore, you are consuming significantly less calories during the course of the day, thus, promoting weight loss.

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When taken with a meal, Xenical prevents utilization of roughly 30 percent of ingested lipids, which pass in the stool, and it reduces absorption of triglycerides and cholesterol to produce a mild hypolipidemic benefit. Given with a balanced diet, it can produce what amounts to a 200-calorie-per-day deficit.

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In contrast to other agents aimed at appetite control, Xenical does not bear the liabilities of elevated blood pressure and heart rate, so it is ideal for patients whose obesity contributes to risks of hypertension, coronary artery disease, stroke and congestive heart failure.

No appreciable effects have been demonstrated on therapeutic levels of antihypertensives, such as furosemide, captopril and atenolol, though a clinicially insignificant change in the tmax of nifedipine was observed. Orlistat showed no effect on the ovulation suppression of oral contraceptives.

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